Bioactive Small Molecules
Medchemexpress LLC (2S)-2-amino-4-phosphonobutanoic acid | 23052-81-5 | MFCD00083244 | 99.0% | 183.10 g/mol | C4H10NO5P | 10 MG
L-AP4 ((2S)-2-amino-4-phosphonobutanoic acid) is a selective agonist of group III metabotropic glutamate receptors (mGluRs) used in neuroscience research to investigate mGluR-mediated signaling and synaptic modulation. It displays submicromolar potency at mGlu4 and mGlu8 and differing activity across other group III subtypes.
Selleck Chemical LLC Dapansutrile S8907-5MG
Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor
Medchemexpress LLC Parp10/15-In-2 | 2892064-99-0 | >=95% | 286.26 | 25 MG
PARP10/15-IN-2 (Compound 8h) is a potent PARP10 and PARP15 dual inhibitor. It can enter cells and rescue them from apoptosis.
- Potent PARP10 and PARP15 dual inhibitor
- IC50 values of 0.15 μM against PARP10
- IC50 values of 0.37 μM against PARP15
- Able to enter cells
- Rescues cells from apoptosis
Cayman Chemical ANTIBODY AZD 8835 10mg
An inhibitor of PI3Kα and PI3Kδ (IC50s = 6.2 and 5.7 nM, respectively); selective for PI3Kα and PI3Kδ over PI3Kβ and PI3Kγ (IC50s = 431 and 90 nM, respectively); inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3Kδ (IC50s = 57 and 49 nM, respectively); reduces tumor growth and Akt phosphorylation in an SKOV3 mouse xenograft model at 25 mg/kg; increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model
Apexbio Technology LLC WEHI-539 hydrochloride, 5mg. Cas: 2070018-33-4 MFCD: MFCD26960962. Bcl-xL inhibitor,high affinity and selective
WEHI-539 hydrochloride is a small-molecule inhibitor of BCL XL with IC50 value of 1.1 nM [1].WEHI-539 was designed as a BCL-XL inhibitor with high affinity. It interacted with the binding groove of BCL-XL with Kd value of 0.6 nM Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC SB 203580 hydrochloride, 50mg. Cas: 869185-85-3 MFCD: MFCD01862622. Specific p38-MAPKs inhibitor
SB203580 HCl is a specific inhibitor of p38-MAPKs with IC50 value of 0.6 M [1].SB203580 is an inhibitor of p38-MAPK and p38-MAPK. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC LDC000067, 50mg. Cas: 1073485-20-7 MFCD: MFCD28137788. CDK9 inhibitor, novel and highly specific
LDC000067 (LDC067) is a novel specific inhibitor of CDK9 with IC50 value of 44 10 nM [1].Cyclin-dependent kinase 9 (CDK9) is a cyclin-dependent kinase. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC HY-109091B 10mg Medchemexpress, Lanraplenib (succinate) CAS:1800047-00-0 Purity:>98%
Medchemexpress, HY-109091B 10mg Lanraplenib (succinate) CAS:1800047-00-0 Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate (GS-9876 succinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 4-HydroxytryptamInfumarate 5mg
An analytical reference standard categorized as a tryptamine; an intermediate in the biosynthesis of psilocybin; intended for research and forensic applications
Cayman Chemical ANTIBODY WAY-181187 10mg
A 5-HT6 receptor agonist; increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM); selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively); selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM; increases extracellular GABA levels in the rat frontal cortex at 10 mg/kg; reduces schedule-induced polydipsia, an adjunctive model of compulsive disorder, in rats at 178 mg/kg; has antidepressant-like activity in rats at 17 mg/kg and anxiolytic-like activity in rats at 10 and 17 mg/kg
Cayman Chemical Daclatasvr 5mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Medchemexpress LLC Genevant CL1 | 1450888-71-7 | >99.9% | C39H73NO2 | 5 MG
Genevant CL1 is an ionizable lipid with a pKa of 6.3, utilized in the formulation of lipid nanoparticles (LNPs) for the efficient delivery of nucleic acid payloads. It plays a crucial role in intramuscular vaccines and is a key component in LNP delivery systems for mRNA vaccines.
- Ionizable lipid with a pKa of 6.3
- Suitable for preparing lipid nanoparticles (LNPs)
- Delivers nucleic acid payloads
- Used in intramuscular vaccines
- Component of LNP delivery systems for mRNA vaccines
Apexbio Technology LLC BMS-777607, 100mg. Cas: 1025720-94-8 MFCD: MFCD16495773. C-Met inhibitor, potent and selective
BMS 777607 is a novel, selective and orally available ATP-competitive MET kinase inhibitor that primarily targets several MET family members, including RON, MET, Tyro-3 and AxI. Other sizes are available. Please inqury us for quote.